Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects.
BACKGROUND Ginger shows promising anticancer properties. No research has examined the pharmacokinetics of the ginger constituents 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in humans. We conducted a clinical trial with 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol, examining the pharmacokinetics and tolerability of these analytes and their conjugate metabolites. METHODS Human vol...
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Candida albicans can form biofilms composed of yeast, hyphal, and pseudohyphal elements, and C. albicans cells in the hyphal stage could be a virulence factor. The present study describes the chemical composition, antibiofilm, and antihyphal activities of cedar leaf essential oil (CLEO), which was found to possess remarkable antibiofilm activity against C. albicans but not to affect its plankto...
متن کاملLiquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida
BACKGROUND The management of Candida infections faces many problems, such as a limited number of antifungal drugs, toxicity, resistance of Candida to commonly antifungal drugs, relapse of Candida infections, and the high cost of antifungal drugs. Though azole antifungal agents and derivatives continue to dominate as drugs of choice against Candida infections, there are many available data refer...
متن کاملPropranolol inhibits hyphal development in Candida albicans.
Propranolol was used to investigate the role of phosphatidic acid (PA) and diacylglycerol in the dimorphic transition in Candida albicans. Propranolol was able to inhibit the appearance of germ tubes without decreasing growth rate. Data suggest that inhibition of morphogenesis may be due to binding by propranolol of PA derived from PLD1 hydrolysis of phosphatidylcholine.
متن کاملGSK-3beta inhibitory effects of 6-gingerol and 6-shogaol help to the recovery of SHSY-5Y cells after amyloid beta1–42 oligomer or aggregate toxicity
BACKGROUND: GSK-3 , has been shown to regulate APP cleavage resulting in the increased production of A and the inhibition of the GSK-3 reduced the amyloid beta induced neurotoxicity in several studies. OBJECTIVE: This study was designed to investigate the GSK-3 inhibitory effects of 6-gingerol and 6-shogaol the major components ofZingiber officinale could be able to recover the SHSY-5Y cells fr...
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ژورنال
عنوان ژورنال: Frontiers in Cellular and Infection Microbiology
سال: 2018
ISSN: 2235-2988
DOI: 10.3389/fcimb.2018.00299